Description

Domperidone is a dopamine antagonist that principally blocks the dopamine receptors located in the Chemoreceptor Trigger Zone (CTZ) and stomach. Its gastroprokinetic action is based on its blocking effect of dopamine receptors, which have an influence on the motility of the gastrointestinal tract. Due to its weak penetration across the blood-brain barrier, domperidone has almost no effect on the dopaminergic receptors in the brain, therefore excluding psychotropic and neurologic side effects. Domperidone restores normal motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis, and regulates contraction of the pylorus. Domperidone also increases esophageal peristalsis, lowers esophageal sphincter pressure, and thus prevents regurgitation of gastric content.

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