Wincef DPS ®
Cephradine is a first generation cephalosporin antibiotic that works in a similar way to penicillin by inhibiting bacterial cell wall synthesis. It has a broad spectrum bactericidal activity against both gram-positive and gram-negative bacteria. The organisms sensitive to Cefradine are group A beta hemolytic streptococci, staphylococci including coagulase-positive, coagulase-negative and penicillinase-producing strains, Streptococcus pneumoniae, Escherichia coli, Proteus mirabillis, Klebsiella species and Hemophilus influenzae. Cefradine is acid stable and is rapidly absorbed after oral administration in the fasting condition. The presence of food in the gastrointestinal tract delays absorption but does not affect the total amount of Cefradine absorbed. Over 90% of the drug is excreted unchanged in the urine. Cefradine is minimally (8 to 17%) bound to normal plasma protein and does not cross the blood-brain barrier.